Tirzepatide vs. Semaglutide
Understand how these two GLP-1 medications differ before discussing your options with a medical provider.
Treatment Class
Dual GLP-1 / GIP receptor agonist
GLP-1 receptor agonist
How It Works
Acts on both GLP-1 and GIP receptors to affect appetite, digestion, and blood sugar regulation.
Acts on GLP-1 receptors to affect appetite, digestion, and blood sugar regulation.
Common Clinical Uses
Type 2 diabetes; chronic weight management in adults with qualifying criteria.
Type 2 diabetes; chronic weight management in adults with qualifying criteria.
Administration
Once-weekly subcutaneous injection.
Once-weekly subcutaneous injection or daily oral tablet.
Monitoring Considerations
Provider may monitor blood sugar, kidney function, and side effects.
Provider may monitor blood sugar, kidney function, and side effects.
Potential Side Effects
May include nausea, diarrhea, vomiting, and decreased appetite. See full prescribing information.
May include nausea, diarrhea, vomiting, and decreased appetite. See full prescribing information.
Important Considerations
Not for use in patients with personal or family history of certain thyroid cancers. Discuss full medical history with your provider.
Not for use in patients with personal or family history of certain thyroid cancers. Discuss full medical history with your provider.
Questions to Discuss With Your Provider
Which medication may be more appropriate for my specific situation?
What monitoring would be needed during treatment?
What are the key differences in side effect profiles?
How do the administration options compare?
Want to discuss these options with a provider?
Start a consultation to discuss which treatment may be appropriate for you.
Start Consultation