Sildenafil vs. Tadalafil
Understand how these two PDE5 inhibitors differ before discussing your options with a medical provider.
Treatment Class
PDE5 inhibitor
PDE5 inhibitor
How It Works
Increases blood flow to the penis in response to sexual stimulation by inhibiting the PDE5 enzyme.
Increases blood flow to the penis in response to sexual stimulation by inhibiting the PDE5 enzyme.
Common Clinical Uses
Treatment of erectile dysfunction.
Treatment of erectile dysfunction and, in some cases, benign prostatic hyperplasia (BPH).
Administration
Taken orally as needed, typically 30–60 minutes before sexual activity.
Taken orally, either as needed or as a daily low-dose medication.
Duration of Action
Generally effective for several hours after dosing.
Longer duration of action, may be effective for up to 36 hours.
Potential Side Effects
May include headache, flushing, indigestion, and nasal congestion. See full prescribing information.
May include headache, indigestion, back pain, muscle aches, and flushing. See full prescribing information.
Important Considerations
Not safe with nitrate medications. Discuss cardiovascular health and all medications with your provider.
Not safe with nitrate medications. Discuss cardiovascular health and all medications with your provider.
Questions to Discuss With Your Provider
Which medication may be more appropriate for my situation?
How do the durations of action compare for my needs?
Is daily dosing or as-needed dosing more appropriate for me?
What monitoring would be needed?
Want to discuss these options with a provider?
Start a consultation to discuss which treatment may be appropriate for you.
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